By Unnamed Unnamed

ISBN-10: 0470513462

ISBN-13: 9780470513460

ISBN-10: 0471910945

ISBN-13: 9780471910947

Until eventually lately a missed disorder syndrome, diarrhea is liable for many thousands of toddler deaths in constructing international locations. the results of a 1987 symposium, this quantity displays advances within the aetiology of diarrhea whereas addressing such perplexing difficulties because the hassle of transforming into viruses in a managed atmosphere. the quantity is intentionally constrained to so-called ``novel'' diarrhea viruses and isn't all for ``classical'' rotaviruses, that have shaped the root of past symposia. Articles be aware of: abnormal rotaviruses; the enteric adenoviruses; small around viruses comparable to astroviruses, caliciviruses and Norwalk virus; and the Berne and Breda viruses, recommended as a brand new kin Toroviridae. The contributions come from an interdisciplinary mixture of virologists (both human and veterinary), epidemiologists, molecular biologists, and pathologists.


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Extra info for Ciba Foundation Symposium 128 - Novel Diarrhoea Viruses

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McCrae: Given the prevalence of antibody to group B in China and the spread there of that virus into humans at a high level, it seems surprising that in Europe group B antibody is frequent in several animal species, so that the virus is occurring, even if not causing disease; yet there is virtually no evidence for a spread into humans. This may indicate some epidemiological factor which is determining the spread of the group B novel rotavirus across the species barrier. Mathan: In children with acute gastroenteritis in southern India, about 10% of the stool samples positive for rotavirus by electron microscopy were ELISAnegative, or atypical.

We can take the cloned cDNAs and sequence them, or look for sequence differences, but both those things are a lot of work and require many isolates where the virulence is known. I can’t think of a human or animal system, other than poliovirus, where it will be easy to do 38 Discussion such studies, because it would not be easy to get biologically well-characterized isolates. Greenberg: You discussed hybridization of your group C genomic probe to both group C and group A RNA, and your group A blot looked positive.

Greenberg: Dr Bishop, with human group C, did you get an abortive infection, or no infection? Bishop: We produced an abortive infection. Any success we may have had was later obscured by overgrowth of a group A rotavirus also present in small numbers in the inoculum. S. Nagesh, has tried primary pig kidney cells and several other cell lines to get a pig atypical virus (group unknown) growing in culture, unsuccessfully. He has tried various proteolytic enzymes and also heparin treatment of the cells, rather than centrifugation, to make the viruses stick to them.

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Ciba Foundation Symposium 128 - Novel Diarrhoea Viruses by Unnamed Unnamed

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